Kambo contains a unique combination of bioactive peptides that interact directly with the nervous system, immune system, gut, and detoxification pathways. These peptides act as messengers helping the body regulate, purge, and restore balance rather than forcing change.
Below are some of the primary peptides identified in Kambo:
Dermorphin
- Powerful endogenous opioid peptide
- May support pain modulation and deep physical release
- Often associated with feelings of relief and calm after ceremony
Deltorphin
- Acts on delta-opioid receptors
- May support emotional regulation and stress response
- Contributes to the grounding, stabilizing effects many people report
Phyllocaerulein
- Supports digestion and bile flow
- Stimulates smooth muscle contraction in the gut
- Often linked to the strong purging response and digestive reset
Phyllomedusin
- Influences vascular and smooth muscle activity
- May support circulation and detoxification processes
- Plays a role in the physical cleansing response
Phyllokinin
- Supports blood flow and lymphatic movement
- May assist with inflammation regulation
- Helps facilitate systemic detoxification
Adenoregulin
- Involved in cellular signaling and energy regulation
- May support nervous system balance and cellular communication
- Associated with feelings of clarity and reset after Kambo
Sauvagine
- Related to stress-response regulation
- May influence adrenal and cortisol-related pathways
- Often discussed in relation to nervous system recalibration
Caerulein
- Stimulates digestive secretions
- Supports gut motility and digestive function
- One of the peptides most associated with digestive clearing
Why This Matters
Rather than working through the mind, Kambo communicates directly with the body through these peptides — activating innate intelligence, detox pathways, and regulatory systems. This is why many people experience both physical purification and nervous system reset, especially when emotional processing and safety are present